| Product Name | Sacsin Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 781-1080 mapping within an internal region of Sacsin of human origin |
| Modification Notes | The SACS gene encodes Sacsin, a protein that plays an important role in chaperone-mediated protein folding and shows predominant expression in the central nervous system. Sacsin expression is also detected in skeletal muscle and pancreas tissues. Sacsin contains 7 nuclear localization signals, 3 coiled-coils, and 2 leucine zipper motifs, in addition to the DnaJ motif and the hydrophobic domain contained within Sacsin’s C-terminal region. Defects in the SACS gene can cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), an early onset neurodegenerative disease characterized by reduced motor-nerve velocity, absent sensory-nerve conduction and hypermyelination of retinal-nerve fibers. ARSACS is highly prevalent in the Charlevoix-Saguenay-Lac-Saint-Jean region of Quebec. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Sacsin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 781-1080 mapping within an internal region of Sacsin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 781-1080 mapping within an internal region of Sacsin of human origin |
| Entrez Gene | 26278 |
|---|
| Application Notes | recommended for detection of Sacsin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
