| Product Name | TSEN54 Antibody (H-132) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 11-142 mapping near the N-terminus of TSEN54 of human origin |
| Modification Notes | The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN54 (tRNA splicing endonuclease 54 homolog), also known as HsSEN54 (SEN54 homolog) or tRNA-intron endonuclease Sen54, is a 526 amino acid protein belonging to the SEN54 family. Localizing to nucleus, TSEN54 is a member of a complex which identifies and cleaves the splice sites in pre-tRNA, and may also be involved in mRNA processing. Defects in TSEN54 may result in pontocerebellar hypoplasia (PCH) type 4 and 2A, characterized by structural abnormalities to the cerebellum, inferior olive, and ventral pons. TSEN54 exists as two alternatively spliced isoforms. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TSEN54 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 11-142 mapping near the N-terminus of TSEN54 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 11-142 mapping near the N-terminus of TSEN54 of human origin |
| Entrez Gene | 283989 |
|---|
| Application Notes | recommended for detection of TSEN54 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
