| Modification Notes |
In humans, the DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT2 (doublesex and mab-3 related transcription factor 2), also known as DSXL2, is a 226 amino acid nuclear protein that contains one DM DNA-binding domain and belongs to the DMRT family. Expressed in kidney, testis and skeletal muscle, DMRT2 shares 80% sequence identity with DMRT1 and may play a role in gonad development. The gene encoding DMRT2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. |