| Product Name | PSMC2 Antibody (H-102) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 29-122 mapping near the N-terminus of PSMC2 of human origin |
| Modification Notes | In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex, and two 19S regulatory particles, which recognize and unfold ubiquitinated proteins. PSMC2 (Proteasome 26S subunit ATPase 2), also known as S7 or MSS1, is a 433 amino acid member of the AAA ATPase family. Localized to both the nucleus and the cytoplasm, PSMC2 functions as a chaperone-like subunit of the 19S regulatory complex where it participates in proteasome events throughout the cell. Additionally, PSMC2 is thought to interact with several basal transcription factors and, via this interaction, may play a role in transcriptional regulation. In response to HIV-1 infection, PSMC2 can positively modulate HIV-1 Tat-mediated transactivation, thereby mediating the interaction between the transcription complex and the viral protein. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PSMC2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 29-122 mapping near the N-terminus of PSMC2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 29-122 mapping near the N-terminus of PSMC2 of human origin |
| Entrez Gene | 5701 |
|---|
| Application Notes | recommended for detection of PSMC2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
