| Product Name | USP9X/Y Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 2248-2547 mapping at the C-terminus of USP9X of human origin |
| Modification Notes | The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP9X (ubiquitin specific peptidase 9, X-linked), also known as FAF or DFFRX, is a 2,547 amino acid member of the peptidase C19 family of ubiquitin proteases. Expressed ubiquitously in both fetal and adult tissue, USP9X is involved in the processing of ubiquitin precursors and ubiquitinated proteins, thereby preventing degradation and regulating protein turnover. USP9Y (ubiquitin specific peptidase 9, Y-linked), another member of the peptidase C19 family, is a 2,555 amino acid protein that is widely expressed and, like USPX, plays an important role in the processing of ubiquitin precursors and of ubiquitinated proteins. Defects in the gene encoding USP9X are implicated in Turner syndrome, a condition in which oocytes fail to proliferate and develop, while defects in the gene encoding USPPY are associated with non-obstructive azoospermia and infertility. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of USP9X and USP9Y of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 2248-2547 mapping at the C-terminus of USP9X of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 2248-2547 mapping at the C-terminus of USP9X of human origin |
| Application Notes | recommended for detection of USP9X and USP9Y of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
