| Product Name | SGK2 Antibody (H-45) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 296-337 mapping within an internal region of SGK2 of human origin |
| Modification Notes | The serum- and glucocorticoid-regulated kinases (SGKs) include SGK1, SGK2 and SGK3 and are members of the serine/threonine protein kinase family. SGKs play an important role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. The SGKs display structural and sequence similarity to the PKB/Akt family except for the absence of a Pleckstrin homology (PH) domain. The SGKs are also downstream targets of PI 3-kinase-stimulated growth factor signaling. They can all phosphorylate NEDD4-1, which subsequently activates various channels and transporters including ENaC, KV1.3 or EAAT1. Aldosterone induces the expression of SGK1, but not SGK2 or SGK3. SGK3 is ubiquitously ex-pressed, but SGK2 only shows significant levels of expression in liver, kidney and pancreas. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SGK2 isoforms 1, 2 and 3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 296-337 mapping within an internal region of SGK2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 296-337 mapping within an internal region of SGK2 of human origin |
| Entrez Gene | 10110 |
|---|
| Application Notes | recommended for detection of SGK2 isoforms 1, 2 and 3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
