Application
Western blot analysis of CYP2S1 expression in non-transfected 293T: (A), human CYP2S1 transfected 293T: (B) and NIH/3T3 (C) whole cell lysates.| Product Name | CYP2S1 Antibody (M-135) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 141-275 mapping within an internal region of CYP2S1 of mouse origin |
| Modification Notes | The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2S1, a member of the CYP2 subfamily, is expressed in a wide variety of epithelial cells in extrahepatic tissues, specifically the respiratory tract, gastrointestinal tract, skin and other tissues frequently exposed to xenobiotics. CYP2S1 localizes to the endoplasmic reticulum where it metabolizes both endogenous and exogenous substrates such as retinoic acid, aromatic hydrocarbons and some cellular substances. CYP2S1 is also involved in the metabolism of topical drugs and mediates the response to photochemotherapy in psoriasis. Dioxin induces CYP2S1, while aryl hydrocarbon receptor (AHR) and aryl hydrocarbon nuclear translocator (ARNT) regulate this induction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CYP2S1 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 141-275 mapping within an internal region of CYP2S1 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 141-275 mapping within an internal region of CYP2S1 of mouse origin |
Application
Western blot analysis of CYP2S1 expression in non-transfected 293T: (A), human CYP2S1 transfected 293T: (B) and NIH/3T3 (C) whole cell lysates.| Application Notes | recommended for detection of CYP2S1 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
