| Product Name | L3MBTL Antibody (H-85) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 581-665 mapping near the C-terminus of L3MBTL of human origin |
| Modification Notes | L3MBTL is member of the Polycomb group of proteins that function as transcriptional repressors in large protein complexes. L3MBTL contains three repeats of 100 residues called MBT repeats, and a C-terminal alpha-helical structure within a cavity lined by aromatic amino acids. The protein undergoes monoallelic methylation in hematopoietic tissues and is expressed in most human adult normal tissues. During interphase, L3MBTL localizes to the nucleus and completely associates with condensed chromosomes in mitotic cells. Together with Trithorax group proteins, L3MBTL is responsible for the coordinated regulation of patterns of gene activity. The human L3MBTL gene lies in a region of chromosome 20 that is frequently deleted in patients with myeloid malignancies and has been proposed as a candidate 20q tumor suppressor gene, implicating L3MBTL expression in some cases of myeloid leukemia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of L3MBTL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 581-665 mapping near the C-terminus of L3MBTL of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 581-665 mapping near the C-terminus of L3MBTL of human origin |
| Entrez Gene | 26013 |
|---|
| Application Notes | recommended for detection of L3MBTL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
