Application
Western blot analysis of STAMBP expression in non-transfected 293T: (A), mouse STAMBP transfected 293T: (B) and HeLa (C) whole cell lysates.Application
Western blot analysis of STAMBP expression in non-transfected: (A) and human STAMBP transfected: (B) 293T whole cell lysates.Application
Western blot analysis of STAMBP expression in non-transfected: (A) and human STAMBP transfected: (B) 293T whole cell lysates.Application
Western blot analysis of STAMBP expression in HeLa whole cell lysate.| Product Name | STAMBP Antibody (M-140) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 131-270 mapping within an internal region of STAMBP of mouse origin |
| Modification Notes | STMBP (STAM binding protein), also known as AMSH, is a 424 amino acid protein belonging to the peptidase M67C family. Ubiquitously expressed, STMBP functions as a zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. STMBP is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. STMBP may play a role in signal transduction for cell growth and Myc induction mediated by IL-2 and GM-CSF. It is suggested that STMBP potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of Smad6 and Smad7. STMBP consists of the JAMM motif, which is essential for the protease activity, and is inhibited by N-ethylmaleimide. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of STAMBP of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 131-270 mapping within an internal region of STAMBP of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 131-270 mapping within an internal region of STAMBP of mouse origin |
Application
Western blot analysis of STAMBP expression in non-transfected 293T: (A), mouse STAMBP transfected 293T: (B) and HeLa (C) whole cell lysates.
Application
Western blot analysis of STAMBP expression in non-transfected: (A) and human STAMBP transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of STAMBP expression in non-transfected: (A) and human STAMBP transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of STAMBP expression in HeLa whole cell lysate.| Application Notes | recommended for detection of STAMBP of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
