Application
Western blot analysis of NMDAε2 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat hippocampal tissue extracts.| Product Name | p-NMDAε2 Antibody (Tyr 1336) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Tyr 1336 phosphorylated NMDAε2 of mouse, rat and human origin by WB and IP |
| Modification | Phosphoralated |
| Modification Notes | Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Lonotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: é 1, 2, 3, 4 and one Ω subunit. The Ω subunit is expressed throughout the brainstem whereas the four é subunits display limited distribution. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIP |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Tyr 1336 phosphorylated NMDA&epsilon 2 of mouse rat and human origin by WB and IP |
|---|---|
| Tissue Specificity | recommended for detection of Tyr 1336 phosphorylated NMDAε2 of mouse, rat and human origin by WB and IP |
| Entrez Gene | 2904 |
|---|
Application
Western blot analysis of NMDAε2 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat hippocampal tissue extracts.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
