| Product Name | PCDH11X/Y Antibody (T-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of PCDH11Y of human origin |
| Modification Notes | Protocadherins (PCDHs) are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH11X (protocadherin 11 X-linked), a 1,347 amino acid protein, and PCDH11Y (protocadherin 11 Y-linked), a 1,340 amino acid protein, are single-pass type I membrane proteins that each contain seven cadherin domains and each exist as multiple alternatively spliced isoforms. Expressed strongly in both adult and fetal brain tissue, PCDH11X and PCDH11Y function as calcium-dependent cell adhesion proteins that are essential for the segmental development and function of the central nervous system. Variations in the PCDH11X and PCDH11Y genes are associated with an increased susceptibility to brain-related afflictions, such as late-onset Alzheimer's disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of PCDH11X and PCDH11Y of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other PCDH11 isoforms also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of PCDH11Y of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of PCDH11Y of human origin |
| Application Notes | recommended for detection of PCDH11X and PCDH11Y of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other PCDH11 isoforms also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
