| Modification Notes |
MEMO1 (mediator of cell motility 1), also known as C2orf4 or NS5ATP7, is a 297 amino acid protein that is thought to relax extracellular chemotactic signals that are targeted at the microtubule cytoskeleton, thereby controlling cell migration. Additionally, MEMO1 is thought to mediate Neu signaling and is required for breast carcinoma migration, suggesting an important role in tumorigenesis. The gene encoding MEMO1 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the chromosome 2-localized ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes, which also map to chromosome 2. |