| Product Name | PDE11A Antibody (H-178) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 373-535 mapping within the GAF1 domain of PDE11A of human origin |
| Modification Notes | cAMP and cGMP are 3',5'-cyclic nucleotides that function as second messengers in a wide variety of signaling pathways throughout the cell. The hydrolysis of cAMP and cGMP to their corresponding 5'-monophosphates (5'-AMP and 5'-GMP, respectively) is catalyzed by 3',5'-cyclic nucleotide phosphodiesterases (PDEs), which provide a means of downregulating cAMP and cGMP signaling. PDE11A (phosphodiesterase 11A), also known as PPNAD2, is a 934 amino acid cytoplasmic protein that belongs to the PDE family. Expressed as four isoforms that exhibit different tissue specificity, PDE11A contains two GAF domains through which it functions to catalyze the H2O-dependent conversion of cAMP and cGMP to their hydrolyzed forms. PDE11A activity is pH-dependent and is regulated by the binding of free cGMP (which acts as an allosteric activator) to the GAF domains, an event that stimulates enzyme activity. Defects in the gene encoding PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2), a bilateral adrenal defect that leads to endocrine-related Cushing syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDE11A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 373-535 mapping within the GAF1 domain of PDE11A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 373-535 mapping within the GAF1 domain of PDE11A of human origin |
| Entrez Gene | 50940 |
|---|
| Application Notes | recommended for detection of PDE11A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
