Application
Western blot analysis of JAZF1 expression in non-transfected: (A) and human JAZF1 transfected: (B) 293T whole cell lysates.| Product Name | JAZF1 Antibody (FL-243) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-243 representing full length JAZF1 of human origin |
| Modification Notes | JAZF1 (juxtaposed with another zinc finger protein 1), also known as TIP27 (TAK1-interacting protein 27) or ZNF802 (zinc finger protein 802), is a 243 amino acid protein that localizes to the nucleus and contains three C2H2-type zinc fingers. Existing as multiple alternatively spliced isoforms, JAZF1 interacts with the nuclear orphan receptor TR4 and is thought to function as a transcriptional repressor, effectively down-regulation the expression of TR4. Chromosomal aberrations in the gene encoding JAZF1 are associated with the pathogenesis of endometrial stromal tumors, suggesting a role for JAZF1 in carcinogenesis. The JAZF1 gene maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of JAZF1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-243 representing full length JAZF1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-243 representing full length JAZF1 of human origin |
| Entrez Gene | 221895 |
|---|
Application
Western blot analysis of JAZF1 expression in non-transfected: (A) and human JAZF1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of JAZF1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
