| Product Name | Lipin-3 Antibody (H-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 250-363 mapping within an internal region of Lipin-3 of human origin |
| Modification Notes | The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2, and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain. Lipin-1 is crucial for normal adipose tissue development and metabolism. Lipin-1 selectively activates a subset of PGC-1å target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARå. Lipin-1 also inactivates the lipogenic program and suppresses circulating lipid levels. Lipin-2 is linked to Majeed syndrome, and autosomal recessive, autoinflammatory disorder. Lipin-3 is an 851 amino acid protein that localizes to the nucleus. Lipin-3 observations are useful in studies related to adipose tissue development in the context of obesity, fatty liver dystrophy, lipodystrophy, insulin resistance and Type 2 diabetes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Lipin-3 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 250-363 mapping within an internal region of Lipin-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 250-363 mapping within an internal region of Lipin-3 of human origin |
| Entrez Gene | 64900 |
|---|
| Application Notes | recommended for detection of Lipin-3 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
