Application
Western blot analysis of cyclin C expression in rat skeletal muscle tissue extract.Application
Western blot analysis of cyclin C expression in non-transfected: (A) and human cyclin C transfected: (B) 293T whole cell lysates.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharinx tissue showing nuclear and cytoplasmic staining of surface epithelial cells (low and high magni?fication). Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Antibodies tested include cyclin C (T-19): (A) and cyclin C (C-19): (B).| Product Name | cyclin C Antibody (T-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of cyclin C of human origin |
| Modification Notes | The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identi- fication of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Cyclin D corresponds to a putative human oncogene designated PRAD1 which maps at the site of the BCL1 rearrangement in certain lymphomas and leukemias. Cyclin C complexes with the cyclin dependent kinase Cdk8. The cyclin C/Cdk8 complex has been shown to have kinase activity toward the carboxy terminal domain of RNA polymerase II. Two complexes have been identified which contain cyclin C/Cdk8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of cyclin C of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of cyclin C of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of cyclin C of human origin |
| Entrez Gene | 892 |
|---|
Application
Western blot analysis of cyclin C expression in rat skeletal muscle tissue extract.
Application
Western blot analysis of cyclin C expression in non-transfected: (A) and human cyclin C transfected: (B) 293T whole cell lysates.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharinx tissue showing nuclear and cytoplasmic staining of surface epithelial cells (low and high magni?fication). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Antibodies tested include cyclin C (T-19): (A) and cyclin C (C-19): (B).| Application Notes | recommended for detection of cyclin C of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
