| Product Name | Corin Antibody (H-220) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 71-290 mapping within a C-terminal extracellular domain of Corin of human origin |
| Modification Notes | Corin, also designated atrial natriuretic peptide-converting enzyme, localizes to the membrane as a single-pass type II membrane protein. Corin acts as a serine protease that utilizes atrial and brain natriuretic peptides (ANP and BNP) as substrates, which play a role in blood coagulation, platelet activation, fibrinolysis, and thrombosis. The extracellular domain of Corin contains two frizzled-like cysteine-rich domains, eight low density lipoprotein receptor (LDLR) repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain at the C-terminus. The frizzled 1 domain and LDLR repeats 1-4 are responsible for substrate recognition. Corin converts Pro-ANP to ANP by cleaving between arginine 123 and serine 124. Corin is highly expressed in cardiomyocytes, and mice deficient in the Corin protein exhibit hypertension and have cardiac hypertrophy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Corin of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 71-290 mapping within a C-terminal extracellular domain of Corin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 71-290 mapping within a C-terminal extracellular domain of Corin of human origin |
| Entrez Gene | 10699 |
|---|
| Application Notes | recommended for detection of Corin of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
