| Product Name | ROS-GC1 Antibody (H-225) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 81-305 mapping within an N-terminal extracellular domain of ROS-GC1 of human origin |
| Modification Notes | Guanylate Cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC) and a membrane-bound receptor form. Rod outer segment membrane guanylate cyclase (ROS-GC) is a critical component of the vertebrate phototransduction machinery. ROS-GC1 is present in the retinal tissue and is localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells. Defects in GUCY2D, the gene encoding ROS-GC1 are a cause of dominant cone-rod dystrophy type 6 (CORD6). CORD6 disease is characterized by the initial degeneration of cone photoreceptor cells, causing early loss of visual acuity and color vision, followed by the degeneration of rod photoreceptor cells leading to progressive night blindness and peripheral visual field loss. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ROS-GC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 81-305 mapping within an N-terminal extracellular domain of ROS-GC1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 81-305 mapping within an N-terminal extracellular domain of ROS-GC1 of human origin |
| Entrez Gene | 3000 |
|---|
| Application Notes | recommended for detection of ROS-GC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
