| Product Name | DCIR Antibody (H-47) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 191-237 mapping within a C-terminal extracellular domain of DCIR of human origin |
| Modification Notes | DCIR (dendritic cell immunoreceptor), is a type II membrane glycoprotein with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif. DCIR is expressed on dendritic cells, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR expression in dendritic cells is decreased by signals inducing its maturation, such as LPS, TNFå or CD40. DCIR contains one copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses such as protein tyrosine phosphorylation and B-cell-receptor-mediated calcium mobilization. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DCIR isoforms 1-4 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 191-237 mapping within a C-terminal extracellular domain of DCIR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 191-237 mapping within a C-terminal extracellular domain of DCIR of human origin |
| Entrez Gene | 50856 |
|---|
| Application Notes | recommended for detection of DCIR isoforms 1-4 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
