| Product Name | ROS-GC2 Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 151-250 mapping within an N-terminal extracellular domain of ROS-GC2 of human origin |
| Modification Notes | Guanylate Cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. Originally identified in bovine retina, rod outer segment membrane guanylate cyclase (ROS-GC) proteins are membrane bound cyclases that serve a key function in photoreceptor physiology. One unique feature of ROS-GCs is that they are not activated by extracellular peptide hormones, but are regulated by calmodulin-like Ca2+-binding proteins GCAP1 and GCAP2. The GCAPs sense changes in intracellular Ca2+ concentration during illumination and activate ROS-GCs when the Ca2+ decreases below 500-600 nM in a dark adapted cell. One feature distinguishing the two forms of ROS-GCs is that ROS-GC1 has two Ca2+ switches and is regulated by GCAP1, whereas ROS-GC2 has only one switch and is regulated by GCAP2. ROS-GC2 also contains a unique stretch of 5 amino acids on its C-terminus which is not present in ROS-GC1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ROS-GC2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 151-250 mapping within an N-terminal extracellular domain of ROS-GC2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 151-250 mapping within an N-terminal extracellular domain of ROS-GC2 of human origin |
| Entrez Gene | 2986 |
|---|
| Application Notes | recommended for detection of ROS-GC2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
