Application
Western blot analysis of DONSON expression in non-transfected: (A) and mouse DONSON transfected: (B) 293T whole cell lysates.Application
Western blot analysis of DONSON expression in HEK 293 whole cell lysate (A) and mouse embryo tissue extract (B).| Product Name | DONSON Antibody (T-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of DONSON of human origin |
| Modification Notes | The smallest of the human chromosomes, 21 makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. The gene encoding DONSON (downstream neighbor of Son) is located on the long arm of chromosome 21 within 65 base pairs of the 3’ end of the SON gene, which encodes a nuclear protein that represses Hep B virus promoter activity and transcription of HBV genes. DONSON is a 566 amino acid nuclear protein that has the ability to be phosphorylated and is possibly required for DNA amplification in the ovary. Also, it is probable that DONSON is needed for cell proliferation during development. There are three isoforms of DONSON which exist as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DONSON of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of DONSON of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of DONSON of human origin |
| Entrez Gene | 29980 |
|---|
Application
Western blot analysis of DONSON expression in non-transfected: (A) and mouse DONSON transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of DONSON expression in HEK 293 whole cell lysate (A) and mouse embryo tissue extract (B).| Application Notes | recommended for detection of DONSON of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
