| Product Name | CRB3 Antibody (H-88) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 27-114 mapping within an internal region of CRB3 of human origin |
| Modification Notes | The transmembrane protein Crumbs plays a crucial role in epithelial cell polarity and photoreceptor development in Drosophila melanogaster embryos, but the first identified human homologue, CRB1, is only expressed in retina and some parts of the brain, leaving room for another homologue to function in epithelial tissues. Leber congenital amaurosis or progressive retinitis pigmentosa are caused by loss of CRB1 function. A second homologue, CRB3, fills the gap, showing expression in epithelial tissues as well as skeletal muscles. CRB3 shares a cytoplasmic domain with other Crumbs proteins, but contains only a very short extracellular domain, through which it interacts with Par6, a regulator of epithelial polarity and tight junction formation. Thus, this specialized isoform provides a connection between apical membrane formation and tight junction regulation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CRB3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 27-114 mapping within an internal region of CRB3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 27-114 mapping within an internal region of CRB3 of human origin |
| Entrez Gene | 92359 |
|---|
| Application Notes | recommended for detection of CRB3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
