| Product Name | Ape2 Antibody (H-250) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against recombinant Ape2 of human origin |
| Modification Notes | Ape2 (Apurinic-apyrimidinic endonuclease 2), also known as APEX nuclease 2 (APEXL2), AP endonuclease XTH2 or DNA-(apurinic or apyrimidinic site) lyase 2, is a member of the AP/exoA family of DNA repair enzymes. Ape2 is ubiquitously expressed and localizes to the nucleus and mitochondria. It is one of the two class II AP endonucleases expressed in mammals (along with Ref-1 (Ape1)). However Ape2 exhibits limited AP-endonuclease activity, and instead primarily functions as a 3’-5’ exonuclease and a 3’-phosphodiesterase. Ape2 associates with PCNA (proliferating cell nuclear antigen) and may play a role in base excision repair (BER), eliminating damaged bases in genomic DNA. Growth retardation and G2/M-phase arrest, exhibited by Ape2-null mice, suggest that Ape2 is also a key player in the proper progression of the cell cycle. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| recommended for detection of Ape2 of human origin by WB: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against recombinant Ape2 of human origin |
|---|---|
| Tissue Specificity | raised against recombinant Ape2 of human origin |
| Entrez Gene | 27301 |
|---|
| Application Notes | recommended for detection of Ape2 of human origin by WB: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
