| Modification Notes |
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B box-type zinc finger, one RING finger and three zinc-binding domains. TRIM proteins are involved in a wide variety of cellular processes such as cell development, proliferation, differentiation, oncogenesis and apoptosis. Many TRIM proteins are induced by type I and type II interferons, making them crucial for development of pathogen-resistance. TRIM65 (tripartite motif containing 65), is a 517 amino acid protein that belongs to the TRIM/RBCC family. Containing a B box-type zinc finger, a B30.2/SPRY domain and a RING-type zinc finger, TRIM65 is encoded by a gene located on human chromosome 17q25.1. Chromosome 17 makes up over 2.5% of the human genome, with about 81 million bases encoding over 1,200 genes. |