Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. Zinc finger and SCAN domain-containing protein 16 (ZSCAN16), also known as ZNF392 or ZNF435, is a 348 amino acid member of the Krüppel C2H2-type zinc finger protein family. Localized to the nucleus, ZSCAN16 contains four C2H2-type zinc fingers at the carboxy terminus and one SCAN box domain, a leucine rich region of about 80 amino acids, at the amino terminus through which it is thought to be involved in DNA-binding and transcriptional regulation. ZSCAN16 has been shown to repress reporter gene transcription, and overexpression of ZNF435 also suppressed the transcriptional activities of AP-1µ. Because AP-1µ is activated by MAPK-mediated phosphorylation, ZNF435 is though to be involved in the MAPK pathway.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZSCAN16 of human origin by WB, IP and ELISA: