SAT-1 (sulfate anion transporter 1), also known as SLC26A1 (solute carrier family 26 (sulfate transporter), member 1) or EDM4, is a 701 amino acid multi-pass membrane protein that belongs to the SLC26A/SulP transporter family of proteins. Members of this family are sulfate/anion transporter proteins that are well conserved in their genomic (number and size of exons) and protein (amino acid length among species) structures, yet they exhibit very restricted and distinct tissue expression patterns. SAT-1 is predominantly expressed in kidney and liver but can also be found at lower levels in spleen, small intestine, brain, pancreas, leukocytes, prostate, thymus, testis and colon. Localized to the plasma membrane, SAT-1 contains one STAS domain, twelve transmembrane domains, two N-glycosylation sites and multiple phosphorylation sites. Accepting oxalate as a cosubstrate, SAT-1 participates in transtubular sulfate reabsorption by mediating the exit of sulfate across the basolateral membrane.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of SAT-1 of human origin by WB, IP, IF, IHC(P) and ELISA: