Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the Krüppel C2H2-type zinc-finger protein family, ZNF322A (zinc finger protein 322A), also designated ZNF388 or ZNF489, is a 402 amino acid protein containing eleven C2H2-type zinc fingers. ZNF322A is localized in both cytoplasm and nucleus and is ubiquitously expressed, with highest expression levels in heart and skeletal muscle. Overexpression of ZNF322A in COS-7 cells leads to transcriptional activation of SRE (serum response element) and c-Jun, suggesting that ZNF322A may function to activate the transcription of target transcription factors that are associated with MAP kinase signaling pathways.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZNF322A of mouse and human origin by WB, IP and ELISA: