Members of the oxysterol-binding protein (OSBP) family function as intracellular lipid receptors. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. ORPs (OSBP-related proteins) belong to a subfamily of OSBPs and consists of ORP-1 through ORP-11. The ORPs have a highly conserved OSBP-type sterol-binding region and a pleckstrin homology domain. They strongly bind to phosphatidic acid and weakly bind to phosphatidylinositol 3-phosphate. ORP-9 is widely expressed, and is produced as two isoforms due to alternative splicing.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of ORP-9 of human and canine origin by WB, IP, IF, IHC(P) and ELISA: