| Product Name | Grid2ip Antibody (M-190) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 91-280 mapping near the N-terminus of Grid2ip of mouse origin |
| Modification Notes | Grid2ip (glutamate receptor, ionotropic, ∂2 (Grid2 or GluR-∂2) interacting protein 1), also known as delphilin, is a postsynaptic scaffolding protein that contains one formin homology 2 (FH2) domain and two PDZ (postsynaptic density-95/discs-large/ZO-1) domains. Expressed in Purkinje cells of the cerebellum and localizing specifically to parallel fiber synapses, Grid2ip interacts with the C-terminus of GluR-∂2 and, via this interaction, links GluR-∂2 with various signaling molecules and the Actin cytoskeleton. GluR-∂2 is a glutamate receptor with an important role in motor learning, cerebellar wiring and synaptic plasticity. Due to alternative splicing events, three Grid2ip isoforms exist, namely L-delphilin, S-delphilin (or delphilin-å) and delphilin-∫. Each isoform exhibits individual expression patterns and protein interactions. Isoform 2, delphilin-å, is palmytoylated, a modification that is essential for the enhanced expression of GluR-∂2 on the cell surface. This modification of delphilin-å also mediates the accumulation of delphilin-å in dendritic spines. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Grid2ip of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 91-280 mapping near the N-terminus of Grid2ip of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 91-280 mapping near the N-terminus of Grid2ip of mouse origin |
| Entrez Gene | 170935 |
|---|
| Application Notes | recommended for detection of Grid2ip of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
