| Product Name | MPV17 Antibody (FL-176) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-176 representing full length MPV17 of mouse origin |
| Modification Notes | MPV17, also known as SYM1, is a 176 amino acid mitochondrial inner membrane protein that belongs to the peroxisomal membrane protein PXMP2/4 family. MPV17 is expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart. MPV17 plays an important role in regulating oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Mutations of MVP17 have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). MDDS is an autosomal recessive trait characterized by a reduction in mitochondrial DNA (mtDNA) copy number. MDDS may affect single organs, typically muscle or liver. Individuals with the hepatocerebral form of MDDS have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MPV17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-176 representing full length MPV17 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-176 representing full length MPV17 of mouse origin |
| Entrez Gene | 4358 |
|---|
| Application Notes | recommended for detection of MPV17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
