| Product Name | Xinα Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 830-1129 mapping at the C-terminus of Xinα of mouse origin |
| Modification Notes | Xinå, also known as CMYA1 ( Cardiomyopathy-associated protein 1) or XIRP1 (xin actin-binding repeat containing 1), is a 1,843 amino acid protein that functions to protect Actin filaments from depolymerization. Colocalized to the cell junction with actin stress fibers, Xinå contains 15 Xin repeats and interacts with several proteins including ∫-catenin, Filamin and VASP (vasodilator-stimulated phosphoprotein). The Xin repeats with the protein are thought to stabilize actin-based cytoskeletons and may help to crosslink microfilaments with actin networks. Xinå shares 78% similarity with its mouse counterpart and is expressed in the heart as three alternatively spliced isoforms designated A, B and C. In mice, Xinå is essential for proper heart tube formation and correct cardiac looping, suggesting that the human homolog may have similar functions. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Xinα of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 830-1129 mapping at the C-terminus of Xin&alpha of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 830-1129 mapping at the C-terminus of Xinα of mouse origin |
| Entrez Gene | 165904 |
|---|
| Application Notes | recommended for detection of Xinα of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
