Application
Western blot analysis of CDD expression in non-transfected 293T: (A), human CDD transfected 293T: (B) and DU 145 (C) whole cell lysates.| Product Name | CDD Antibody (FL-146) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-146 representing full length CDD of human origin |
| Modification Notes | Cytidine deaminase (CDD or CDA) is a member of the cytidine and deoxycytidylate deaminase family of proteins. CDD catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. Ara-C is used in the treatment of acute myeloid leukemia (AML), and the antileukemic activity of the drug is contingent on phosphorylation by deoxycytidine kinase (DCK). Resistance to Ara-C is a major determinant of unsucessful AML treatment, the failure of which has been attributed to a DCK functional defect and increased CDD activity. CDD also scavenges endogenous and exogenous cytidine and 2’-deoxycytidine for UMP synthesis. CDD can form homotetramers and is mainly expressed in granulocytes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CDD (Cytidine deaminase) of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-146 representing full length CDD of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-146 representing full length CDD of human origin |
| Entrez Gene | 978 |
|---|
Application
Western blot analysis of CDD expression in non-transfected 293T: (A), human CDD transfected 293T: (B) and DU 145 (C) whole cell lysates.| Application Notes | recommended for detection of CDD (Cytidine deaminase) of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
