Application
Western blot analysis of β-parvin expression in mouse liver (A) and mouse skeletal muscle (B) tissue extracts.| Product Name | β-parvin Antibody (H-45) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 197-241 mapping within an internal region of β-parvin of human origin |
| Modification Notes | The parvin family, including å-parvin, ∫-parvin and ©-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, å-actinin and testicular kinase 1. å-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of å-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. ∫-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-©-parvin complex is essential for the establishment of cell polarity required for leukocyte migration. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of β-parvin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 197-241 mapping within an internal region of β-parvin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 197-241 mapping within an internal region of β-parvin of human origin |
| Entrez Gene | 29780 |
|---|
Application
Western blot analysis of β-parvin expression in mouse liver (A) and mouse skeletal muscle (B) tissue extracts.| Application Notes | recommended for detection of β-parvin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
