| Product Name | NPC1L1 Antibody (M-220) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 21-240 mapping within an N-terminal extracellular domain of NPC1L1 of mouse origin |
| Modification Notes | Niemann-Pick disease type C (NPC) is an autosomal recessive disease characterized by the accumulation of unesterified cholesterol in the endosomal/lysosomal system, which results in progressive neurodegeneration and death. Niemann-Pick C1-like protein 1 precusor, or NPC1L1, is a membrane protein involved in the uptake of cholesterol at the intestinal enterocyte across the plasma membrane. NPC1L1 is widely expressed and is the target of ezetimibe, a drug involved in the inhibition of cholesterol absorption. In human, mouse and rat, small intestine tissue shows the highest level of NPC1L1 expression; expression in other tissues includes gallbladder, liver, testis and stomach. The NPC1L1 gene contains 20 exons, with an unusually large 1,526 bp exon 2, and spans approximately 29 kb. The presumed promoter region of the gene harbors a sterol-regulatory element (SRE) for SRE-binding protein, further suggesting that NPC1L1 may play a role in subcellular cholesterol homeostasis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NPC1L1 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-240 mapping within an N-terminal extracellular domain of NPC1L1 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-240 mapping within an N-terminal extracellular domain of NPC1L1 of mouse origin |
| Entrez Gene | 29881 |
|---|
| Application Notes | recommended for detection of NPC1L1 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
