Application
Western blot analysis of BMP-8 expression in non-transfected: (A) and human BMP-8 transfected: (B) 293T whole cell lysates.| Product Name | BMP-5/6/7/8 Antibody (H-44) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 407-450 of BMP-5 of human origin |
| Modification Notes | Bone morphogenic proteins (BMPs) are members of the TGF∫superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGF∫ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BMP-5, BMP-6, BMP-7 and BMP-8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 407-450 of BMP-5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 407-450 of BMP-5 of human origin |
| Entrez Gene | 653 |
|---|
Application
Western blot analysis of BMP-8 expression in non-transfected: (A) and human BMP-8 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of BMP-5, BMP-6, BMP-7 and BMP-8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
