epitope corresponding to amino acids 281-390 mapping within an internal region of Fcrl5 of mouse origin
Modification Notes
The Fc receptor homolog (FcRH) family of proteins are related to the classical Fc receptors (FcR) and belong to the immunoglobulin receptor superfamily. The proteins in the FcRH family (namely FcRH1-FcRH6) are type I transmembrane glycoproteins that are involved in immune system regulation and have immunoreceptor-tyrosine inhibitory motifs in their cytoplasmic domains. Fcrl5 (Fc receptor-like protein 5), also known as Fcrh3 (Fc receptor homolog 3), is a 596 amino acid single-pass type I membrane protein that is the mouse homolog of human FcRH3. Localized to the cell membrane and expressed in marginal zone B cells, Fcrl5 contains five Ig-like C2-type domains and is thought to function as an inhibitory coreceptor for B cells. Two isoforms of Fcrl5 exist due to alternative splicing events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of Fcrl5 of mouse and, to a lesser extent, rat origin by WB, IP, IF and ELISA:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 281-390 mapping within an internal region of Fcrl5 of mouse origin
Tissue Specificity
epitope corresponding to amino acids 281-390 mapping within an internal region of Fcrl5 of mouse origin