| Product Name | EZI Antibody (H-76) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 164-239 mapping within an internal region of EZI of human origin |
| Modification Notes | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Krueppel C2H2-type zinc-finger protein family, EZI, also known as ZNF467 (zinc finger protein 467) or Zfp467, is a 595 amino acid nuclear protein that contains twelve C2H2-type zinc fingers. EZI interacts with Stat3, thereby keeping it in the nucleus and enhancing Stat3 activity. Involved in transcriptional regulation, EZI transactivates several promoters including c-Fos and OSM. EZI is considered a novel cargo protein for importin-7 and is able to perform a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of EZI of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 164-239 mapping within an internal region of EZI of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 164-239 mapping within an internal region of EZI of human origin |
| Application Notes | recommended for detection of EZI of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
