Application
Western blot analysis of Crry expression in non-transfected: (A) and mouse Crry transfected: (B) 293T whole cell lysates and rat spleen tissue extract.Application
Western blot analysis Crry expression in rat kidney tissue extract.| Product Name | Crry Antibody (M-180) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 121-300 mapping within an internal region of Crry of mouse origin |
| Modification Notes | Human membrane cofactor protein (MCP), also designated CD46, is a widely distributed complement regulator. In mouse, expression of MCP is largely restricted to testis, while a related widely expressed protein (Crry) appears to perform the regulatory activity of MCP. Crry (for murine complement receptor-related gene Y), protects the body from damage inflicted by inflammation and modulates renal interstitial disease induced by proteinuria. A functional ortholog of human decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46), Crry protects cells from homologous complement by inhibiting the complement proteins C3 and C4 convertases from marking foreign cells for destruction. Sequence analysis suggests that Crry may be the mouse genetic homolog of the CD35 antigen encoded by the human gene CR1. Manipulation of Crry may play a role in treating central nervous conditions such as traumatic brain injury or stroke. Deletion of the gene encoding Crry may play a role in miscarriages. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Crry of mouse and rat origin and, to a lesser extent, CD35 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 121-300 mapping within an internal region of Crry of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 121-300 mapping within an internal region of Crry of mouse origin |
| Entrez Gene | 1379 |
|---|
Application
Western blot analysis of Crry expression in non-transfected: (A) and mouse Crry transfected: (B) 293T whole cell lysates and rat spleen tissue extract.
Application
Western blot analysis Crry expression in rat kidney tissue extract.| Application Notes | recommended for detection of Crry of mouse and rat origin and, to a lesser extent, CD35 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
