| Product Name | p-B-ATF Antibody (Thr 48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Thr 48 of B-ATF of human origin |
| Modification | Phosphoralated |
| Modification Notes | B-ATF is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors (1-5). The leucine zipper of B-ATF mediates dimerization with members of the Jun family of proteins (1). The B-ATF protein does not homodimerize efficiently, but rather forms a heterodimer preferentially with c-Jun (4). The B-ATF/c-Jun protein complex can interact with DNA containing a consensus binding site for AP-1, suggesting that B-ATF functions as a tissue-specific modulator of the AP-1 transcription complex in human cells (3). B-ATF also associates with IFP35, a leucine zipper protein that translocates to the nucleus following IFN treatment (4). The gene encoding B-ATF, also designated SFA-2, is strongly expressed in mature T and B lymphocytes, and is up-regulated after transformation by human T-cell leukemia virus type I (5). Phosphorylation of BATF on Ser43 and Thr48 regulates DNA binding. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Thr 48 phosphorylated B-ATF of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Thr 48 of B-ATF of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Thr 48 of B-ATF of human origin |
| Entrez Gene | 10538 |
|---|
| Application Notes | recommended for detection of Thr 48 phosphorylated B-ATF of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
