| Product Name | Agmatinase Antibody (H-108) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 53-160 mapping within an internal region of Agmatinase of human origin |
| Modification Notes | Agmatinase (also known as agmatine ureohydrolase) results from the decarboxylation of L-arginine by arginine decarboxylase to form a metabolic intermediate in the biosynthesis of putresine and higher polyamines (spermidine and spermine). Agmatinase has been shown to play a role in several important biochemical processes in humans, ranging from effects on the central nervous system to cell proliferation in cancer and viral replication. Agmatinase catalyzes the hydrolysis of agmatine to putresine and urea and is a major target for drug therapy. Human Agmatinase retains about 30% identity to bacterial agmatinases and less than 20% identity to mammalian arginases. Residues required for binding of Mn2+ at the active site in bacterial Agmatinase and other members of the arginase superfamily are fully conserved in human Agmatinase. Agmatinase mRNA is most abundant in human liver and kidney, but is also expressed in several other tissues, including skeletal muscle and brain. Expression of Agmatinase mRNA in human liver is induced during hepatitis B virus infection, suggesting that Agmatinase may contribute to the pathophysiology of this disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Agmatinase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 53-160 mapping within an internal region of Agmatinase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 53-160 mapping within an internal region of Agmatinase of human origin |
| Entrez Gene | 79814 |
|---|
| Application Notes | recommended for detection of Agmatinase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
