Application
Western blot analysis of HNMT expression in human liver tissue extract.| Product Name | HNMT Antibody (FL-292) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-292 representing full length HNMT of human origin |
| Modification Notes | Histamine is a biogenic amine that functions as a neurotransmitter in the gut and plays an important role in the immune system, specifically by dilating blood vessels in response to allergic reactions. HNMT (Histamine N-methyltransferase), also known as HMT, HNMT-S1 or HNMT-S2, is a 292 amino acid protein that exists as a monomer and belongs to the methyltransferase superfamily. Localized to the cytoplasm, HNMT catalytically inactivates histamine by N-methylation and, via this inactivation, plays an essential role in the degradation of histamine. Through its ability to regulate and reduce the amount of histamine within the cell, HNMT participates in the airway response and limits the severity of allergic reactions. A common genetic polymorphism in HNMT may be linked to a predisposition to asthma. HNMT is expressed as multiple isoforms due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of HNMT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-292 representing full length HNMT of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-292 representing full length HNMT of human origin |
| Entrez Gene | 3176 |
|---|
Application
Western blot analysis of HNMT expression in human liver tissue extract.| Application Notes | recommended for detection of HNMT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
