| Modification Notes |
SSK1 (osomolarity two-component system protein SSK1) is a 712 amino acid cytoplasmic protein. SSK1 is the final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which, in response to changes in the osmolarity of the extracellular environment, regulates the activity of the Hog1 pathway. During normal osmolarity, the phosphorelay intermediate protein YPD1 maintains SSK1 in a phosphorylated and inactive state. Under high osmolarity conditions, the unphosphorylated form of SSK1 activates SSK2 and SSK22, proteins which further stimulate the PBS2-HOG1 MAPKK-MAPK pathway. |