| Modification Notes |
Signaling lymphocyte-activation molecule (SLAM), also designated CDw150, is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. SLAM is expressed on B and T lymphocytes, dendritic cells and endothelial cells, and is thought to be a marker of activated B and T lymphocytes. SLAM family member 9 (SLAMF9), also designated CD2F-10 or CD84 homolog 1, is a 289 amino acid protein that shares 58% identity with the mouse protein. The SLAMF9 protein is predominantly expressed in hematopoietic tissues and contains a 19-residue signal peptide, an extracellular region with only two N-linked glycosylation sites, a 20-residue transmembrane region and a highly positively charged 30-residue cytoplasmic tail, suggesting a role for SLAMF9 as an adhesion molecule. SLAMF9 may function in the immune response as a coreceptor for lymphocyte activation. |