Application
Western blot analysis of FBP1 expression in non-transfected: (A) and human FBP1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of FBP1 expression in non-transfected: (A) and mouse FBP1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of FBP1 expression in AML-193 whole cell lysate.| Product Name | FBP1 Antibody (H-42) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 65-106 mapping near the N-terminus of FBP1 of human origin |
| Modification Notes | Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of FBP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 65-106 mapping near the N-terminus of FBP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 65-106 mapping near the N-terminus of FBP1 of human origin |
| Entrez Gene | 8880 |
|---|
Application
Western blot analysis of FBP1 expression in non-transfected: (A) and human FBP1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of FBP1 expression in non-transfected: (A) and mouse FBP1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of FBP1 expression in AML-193 whole cell lysate.| Application Notes | recommended for detection of FBP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
