| Modification Notes |
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC35 (tetratricopeptide repeat domain 35), also known as KIAA0103, is a 297 amino acid protein that contains 3 tetratricopeptide repeats and localizes to the inner nuclear membrane. Its similarity to the Nicotiana tabacum GlcNAc transferase protein suggests that TTC35 may be a putative O-linked glycosyl transferase. |