| Modification Notes |
Lipids in biological membranes are distributed asymmetrically across the bilayer with choline-containing lipids and sphingolipids on the extracellular surface and amine-containing phospholipids on the cytoplasmic surface. Phospholipid asymmetry is necessary for normal membrane function and disruption of asymmetry is associated with pathological conditions. The plasma membrane maintains lipid asymmetry via actions of aminophospholipid translocase, floppase and lipid scramblases. The phospholipid scramblase (PLS) family consists of membrane-bound enzymes that participate in the bi-directional movement of phospholipids. PLSCR5 (phospholipid scramblase 5) is a 271 amino acid calcium-dependent mitochondrial membrane protein that is a member of the phospholipid scramblase (PLS) family. The gene encoding PLSCR5 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. |