| Modification Notes |
RILP (Rab interacting lysosomal protein), also known as PP10141, is a 401 amino acid protein that contains one RILP-like domain and localizes to cytoplasmic vesicles, as well as to the late endosome membrane and the intracytoplasmic membrane. Expressed ubiquitously with strongest expression in spleen, heart, stomach, liver, lung and salivary gland, RILP exists as a homodimer that affects Rab function and plays an important role in late endocytic transport to degradative compartments. In addition, RILP is involved in the recruitment of Dynein-Dynactin motor complex to late endosomes and also participates in the regulation of lysosomal morphology and distribution. Two isoforms of RILP exist due to alternative splicing events. |