| Modification Notes |
Proteins containing RNA recognition motifs, including various hnRNP proteins, are implicated in the regulation of alternative splicing and protein components of snRNPs. The RBM (RNA-binding motif) gene family encodes proteins with an RNA binding motif that have been suggested to play a role in the modulation of apoptosis. RBM11 (RNA-binding protein 11) is a 281 amino acid nuclear protein that contains one RNA recognition motif. RBM11 exists as two isoforms produced by alternative splicing and is expressed in testis, kidney, spleen, brain, spinal cord and mammary gland. The gene that encodes RBM11 maps to chromosome 21, the smallest of the human chromosomes. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. |