| Product Name | Hdf1 Antibody (y-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 303-602 mapping at the C-terminus of Hdf1 of Saccharomyces cerevisiae origin |
| Modification Notes | Telomeric DNA is bound by the transcription regulator Rap1 (repressor activator protein 1, also designated Grf1). In addition to playing a role in silencing the HM mating-type loci, Rap1 is involved in the repression of genes located adjacent to the telomeres, a phenomenon known as telomere position effect (TPE) (1). The silent information regulator proteins Sir2 (also designated Mar1), Sir3 (also designated Mar2, Ste8 or Cmt1) and SIR4 (also designated Ste9, Asd1 or Uth2) form a complex with Rap1 (2,3). These proteins are essential for TPE silencing and HM structure. Sir1 is essential for silencing the HM mating-type loci, but it has no effect on Tpe (4). Tel1, a member of the PI 3-kinase family and a homolog of the human ataxia telangiectasia protein, is involved in controlling telomere length (5). Hdf1 (also referred to as Ku-70), a homolog of the mammalian Ku-70, also plays a role in maintaining telomere length (6). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Hdf1 of Saccaromyces cerevisiae origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 303-602 mapping at the C-terminus of Hdf1 of Saccharomyces cerevisiae origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 303-602 mapping at the C-terminus of Hdf1 of Saccharomyces cerevisiae origin |
| Application Notes | recommended for detection of Hdf1 of Saccaromyces cerevisiae origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
