Application
Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoskeletal localization.Application
Western blot analysis of Strumpellin expression in HeLa (A), Ramos (B), Hep G2 (C) and DU 145 (D) whole cell lysates.| Product Name | Strumpellin Antibody (C-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of Strumpellin of human origin |
| Modification Notes | Strumpellin, also known as SPG8 or KIAA0196, is a 1,159 amino acid ubiquitously expressed protein that is present at higher levels in skeletal muscle and prostate cancer cells, suggesting a role in tumorigenesis. Defects in the gene encoding Strumpellin are the cause of autosomal dominant spastic paraplegia type 8 (SPG8), characterized by the slow and gradual weakening of the legs, as well as muscle spasms, stiffness and incontinence. The gene encoding Strumpellin maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Strumpellin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of Strumpellin of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of Strumpellin of human origin |
| Entrez Gene | 9897 |
|---|
Application
Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoskeletal localization.
Application
Western blot analysis of Strumpellin expression in HeLa (A), Ramos (B), Hep G2 (C) and DU 145 (D) whole cell lysates.| Application Notes | recommended for detection of Strumpellin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
